Psychedelic Substances: FAQs on Effects, Safety, and Therapy

Nordstrom et al. (2008) used 11CN-methylspiperone (NMS) PET analysis in four human subjects with the 5-HT2A receptor inverse agonist ACP-103 N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide. Cortical 11CNMS binding was measured by PET after escalating single oral doses of ACP-103.